3LC3

Benzothiophene Inhibitors of Factor IXa

3LC3 の概要

• エントリーDOI: 10.2210/pdb3lc3/pdb
• 関連するPDBエントリー: 3LC5
• 分子名称: Coagulation factor IX, 1-[5-(3,4-dimethoxyphenyl)-1-benzothiophen-2-yl]methanediamine, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor complex, peptidase s1, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hemophilia, hydrolase, hydroxylation, pharmaceutical, phosphoprotein, polymorphism, protease, secreted, serine protease, sulfation, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00740 P00740
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66231.67

構造登録者

Wang, S.,Beck, R. (登録日: 2010-01-09, 公開日: 2010-02-23, 最終更新日: 2011-07-13)

• 主引用文献: Wang, S.,Beck, R.,Blench, T.,Burd, A.,Buxton, S.,Malic, M.,Ayele, T.,Shaikh, S.,Chahwala, S.,Chander, C.,Holland, R.,Merette, S.,Zhao, L.,Blackney, M.,Watts, A.; Studies of Benzothiophene Template as Potent Factor IXa (FIXa) Inhibitors in Thrombosis.; J.Med.Chem., 53:1465-1472, 2010; PubMed: 20121198; DOI: 10.1021/jm901475e

実験手法

X-RAY DIFFRACTION (1.9 Å)