3LBZ
Crystal Structure of the BCL6 BTB domain complexed with the small molecule inhibitor 79-6
Summary for 3LBZ
Entry DOI | 10.2210/pdb3lbz/pdb |
Descriptor | B-cell lymphoma 6 protein, N-[(4-bromophenyl)sulfonyl]acetamide, (2R)-2-[(5Z)-5-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanedioic acid, ... (4 entities in total) |
Functional Keywords | transcription regulation, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P41182 |
Total number of polymer chains | 2 |
Total formula weight | 31047.72 |
Authors | Ghetu, A.F.,Prive, G.G. (deposition date: 2010-01-08, release date: 2010-04-28, Last modification date: 2023-09-06) |
Primary citation | Cerchietti, L.C.,Ghetu, A.F.,Zhu, X.,Da Silva, G.F.,Zhong, S.,Matthews, M.,Bunting, K.L.,Polo, J.M.,Fares, C.,Arrowsmith, C.H.,Yang, S.N.,Garcia, M.,Coop, A.,Mackerell, A.D.,Prive, G.G.,Melnick, A. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell, 17:400-411, 2010 Cited by PubMed: 20385364DOI: 10.1016/j.ccr.2009.12.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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