3LAU

Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor

Summary for 3LAU

Entry DOI	10.2210/pdb3lau/pdb
Descriptor	Serine/threonine-protein kinase 6, N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]butanamide (3 entities in total)
Functional Keywords	kinase inhibitor complex, atp-binding, cell cycle, cytoplasm, cytoskeleton, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, ubl conjugation
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	33637.51
Authors	Maignan, S.,Guilloteau, J.P.,Pouzieux, S. (deposition date: 2010-01-07, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citation	Lesuisse, D.,Dutruc-Rosset, G.,Tiraboschi, G.,Dreyer, M.K.,Maignan, S.,Chevalier, A.,Halley, F.,Bertrand, P.,Burgevin, M.C.,Quarteronet, D.,Rooney, T. Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20:1985-1989, 2010 Cited by PubMed Abstract: From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2. PubMed: 20167481 DOI: 10.1016/j.bmcl.2010.01.114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation