3LAL
Crystal structure of HIV-1 reverse transcriptase in complex with N1-ethyl pyrimidinedione non-nucleoside inhibitor
Summary for 3LAL
Entry DOI | 10.2210/pdb3lal/pdb |
Related | 3LAK 3LAM 3LAN |
Descriptor | HIV Reverse transcriptase, 3-{[3-ethyl-5-(1-methylethyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]carbonyl}-5-methylbenzonitrile, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hiv, rt, nnrti, transferase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 |
Total number of polymer chains | 2 |
Total formula weight | 129931.57 |
Authors | Lansdon, E.B.,Mitchell, M.L. (deposition date: 2010-01-06, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Mitchell, M.L.,Son, J.C.,Guo, H.,Im, Y.A.,Cho, E.J.,Wang, J.,Hayes, J.,Wang, M.,Paul, A.,Lansdon, E.B.,Chen, J.M.,Graupe, D.,Rhodes, G.,He, G.X.,Geleziunas, R.,Xu, L.,Kim, C.U. N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 20:1589-1592, 2010 Cited by PubMed: 20138513DOI: 10.1016/j.bmcl.2010.01.085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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