3L9H
X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085
3L9H の概要
エントリーDOI | 10.2210/pdb3l9h/pdb |
分子名称 | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, 1-[2-(dimethylamino)ethyl]-3-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl}urea, ... (4 entities in total) |
機能のキーワード | mitotic spindle kinesin, eg5, small molecule inhibitor, emd 534085, acetylation, atp-binding, cell cycle, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein, polymorphism |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P52732 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 83918.63 |
構造登録者 | |
主引用文献 | Schiemann, K.,Finsinger, D.,Zenke, F.,Amendt, C.,Knochel, T.,Bruge, D.,Buchstaller, H.P.,Emde, U.,Stahle, W.,Anzali, S. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg.Med.Chem.Lett., 20:1491-1495, 2010 Cited by PubMed: 20149654DOI: 10.1016/j.bmcl.2010.01.110 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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