3L8V

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor

3L8V の概要

• エントリーDOI: 10.2210/pdb3l8v/pdb
• 分子名称: Hepatocyte growth factor receptor, 2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-N-(2,4-difluorophenyl)pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase, alternative splicing, chromosomal rearrangement, disease mutation, kinase, polymorphism, receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35886.43

構造登録者

Sack, J. (登録日: 2010-01-04, 公開日: 2010-05-05, 最終更新日: 2023-09-06)

• 主引用文献: Williams, D.K.,Chen, X.T.,Tarby, C.,Kaltenbach, R.,Cai, Z.W.,Tokarski, J.S.,An, Y.,Sack, J.S.,Wautlet, B.,Gullo-Brown, J.,Henley, B.J.,Jeyaseelan, R.,Kellar, K.,Manne, V.,Trainor, G.L.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M.; Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.; Bioorg.Med.Chem.Lett., 20:2998-3002, 2010; PubMed: 20382527; DOI: 10.1016/j.bmcl.2010.01.042

実験手法

X-RAY DIFFRACTION (2.4 Å)