3L6J

Structure of cinaciguat (bay 58-2667) bound to nostoc H-NOX domain

Summary for 3L6J

• Entry DOI: 10.2210/pdb3l6j/pdb
• Related: 2O09 2O0C 2O0G
• Descriptor: Alr2278 protein, 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid (3 entities in total)
• Functional Keywords: guanylyl cyclase, bay58-2667, signaling protein
• Biological source: Nostoc sp.
• Total number of polymer chains: 2
• Total formula weight: 43558.68

Authors

Martin, F.,van den Akker, F. (deposition date: 2009-12-23, release date: 2010-05-12, Last modification date: 2023-09-06)

• Primary citation: Martin, F.,Baskaran, P.,Ma, X.,Dunten, P.W.,Schaefer, M.,Stasch, J.P.,Beuve, A.,van den Akker, F.; Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.; J.Biol.Chem., 285:22651-22657, 2010; PubMed: 20463019; DOI: 10.1074/jbc.M110.111559

Experimental method

X-RAY DIFFRACTION (2.3 Å)