3L4C

Structural basis of membrane-targeting by Dock180

Summary for 3L4C

Entry DOI	10.2210/pdb3l4c/pdb
Descriptor	Dedicator of cytokinesis protein 1, BETA-MERCAPTOETHANOL (3 entities in total)
Functional Keywords	dock180, dock1, phosphoinositide specificity, guanine exchange factor, rho gtpase, cytoskeleton, cell migration, cell polarity, apoptosis, cytoplasm, guanine-nucleotide releasing factor, membrane, phagocytosis, phosphoprotein, sh3 domain, sh3-binding, cell adhesion, cell invasion
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q14185
Total number of polymer chains	2
Total formula weight	49499.81
Authors	Premkumar, L.,Bobkov, A.A.,Patel, M.,Jaroszewski, L.,Bankston, L.A.,Stec, B.,Vuori, K.,Cote, J.-F.,Liddington, R.C. (deposition date: 2009-12-18, release date: 2010-02-23, Last modification date: 2023-09-06)
Primary citation	Premkumar, L.,Bobkov, A.A.,Patel, M.,Jaroszewski, L.,Bankston, L.A.,Stec, B.,Vuori, K.,Cote, J.F.,Liddington, R.C. Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J.Biol.Chem., 285:13211-13222, 2010 Cited by PubMed: 20167601 DOI: 10.1074/jbc.M110.102517 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation