3L3R

Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants

3L3R の概要

• エントリーDOI: 10.2210/pdb3l3r/pdb
• 関連するPDBエントリー: 3F8Y
• 分子名称: Dihydrofolate reductase, 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, antifolate, active site mutants, nadp, one-carbon metabolism, oxidoreductase
• 由来する生物種: Homo sapiens
• 細胞内の位置: Mitochondrion : P00374
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22527.25

構造登録者

Cody, V. (登録日: 2009-12-17, 公開日: 2011-01-05, 最終更新日: 2023-09-06)

• 主引用文献: Cody, V.,Pace, J.,Queener, S.F.,Adair, O.O.,Gangjee, A.; Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.; Antimicrob.Agents Chemother., 57:2669-2677, 2013; PubMed: 23545530; DOI: 10.1128/AAC.00172-13

実験手法

X-RAY DIFFRACTION (2 Å)