3L11

Crystal Structure of the Ring Domain of RNF168

3L11 の概要

• エントリーDOI: 10.2210/pdb3l11/pdb
• 分子名称: E3 ubiquitin-protein ligase RNF168, ZINC ION, MALONATE ION, ... (4 entities in total)
• 機能のキーワード: e3 ligase, ring domain, dna damage, chromatin regulator, chromosomal protein, dna repair, ligase, metal-binding, nucleus, phosphoprotein, ubl conjugation pathway, zinc-finger, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q8IYW5
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13466.16

構造登録者

Neculai, D.,Yermekbayeva, L.,Crombet, L.,Weigelt, J.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (登録日: 2009-12-10, 公開日: 2010-01-19, 最終更新日: 2023-09-06)

• 主引用文献: Campbell, S.J.,Edwards, R.A.,Leung, C.C.,Neculai, D.,Hodge, C.D.,Dhe-Paganon, S.,Glover, J.N.; Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.; J.Biol.Chem., 287:23900-23910, 2012; PubMed: 22589545; DOI: 10.1074/jbc.M112.359653

実験手法

X-RAY DIFFRACTION (2.12 Å)