3L0J

Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand

Summary for 3L0J

Entry DOI	10.2210/pdb3l0j/pdb
Descriptor	Nuclear receptor ROR-gamma, Nuclear receptor coactivator 2, (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, ... (4 entities in total)
Functional Keywords	ror gamma, nuclear receptors, alternative splicing, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, acetylation, activator, phosphoprotein, polymorphism
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (Probable): P51449 Nucleus: Q15596
Total number of polymer chains	2
Total formula weight	29935.94
Authors	Martynowski, D.,Li, Y. (deposition date: 2009-12-10, release date: 2010-03-16, Last modification date: 2024-02-21)
Primary citation	Jin, L.,Martynowski, D.,Zheng, S.,Wada, T.,Xie, W.,Li, Y. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol.Endocrinol., 24:923-929, 2010 Cited by PubMed: 20203100 DOI: 10.1210/me.2009-0507 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation