3KY9

Autoinhibited Vav1

Summary for 3KY9

• Entry DOI: 10.2210/pdb3ky9/pdb
• Descriptor: Proto-oncogene vav, ZINC ION (2 entities in total)
• Functional Keywords: vav1, calponin homology domain, dbl homology domain, pleckstrin homology domain, c1 domain, guanine-nucleotide releasing factor, metal-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, zinc-finger, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 137668.68

Authors

Tomchick, D.R.,Rosen, M.K.,Machius, M.,Yu, B. (deposition date: 2009-12-04, release date: 2010-02-23, Last modification date: 2011-07-13)

• Primary citation: Yu, B.,Martins, I.R.,Li, P.,Amarasinghe, G.K.,Umetani, J.,Fernandez-Zapico, M.E.,Billadeau, D.D.,Machius, M.,Tomchick, D.R.,Rosen, M.K.; Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1; Cell(Cambridge,Mass.), 140:246-256, 2010; PubMed: 20141838; DOI: 10.1016/j.cell.2009.12.033

Experimental method

X-RAY DIFFRACTION (2.731 Å)