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3KY2

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

Summary for 3KY2
Entry DOI10.2210/pdb3ky2/pdb
Related3KXX
DescriptorBasic fibroblast growth factor receptor 1, SULFATE ION (3 entities in total)
Functional Keywordskinase, rtk, phosphorylation, interface, alternative splicing, atp-binding, chromosomal rearrangement, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight72837.46
Authors
Bae, J.H.,Boggon, T.J.,Tome, F.,Mandiyan, V.,Lax, I.,Schlessinger, J. (deposition date: 2009-12-04, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citationBae, J.H.,Boggon, T.J.,Tome, F.,Mandiyan, V.,Lax, I.,Schlessinger, J.
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107:2866-2871, 2010
Cited by
PubMed: 20133753
DOI: 10.1073/pnas.0914157107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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