3KY2

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

3KY2 の概要

• エントリーDOI: 10.2210/pdb3ky2/pdb
• 関連するPDBエントリー: 3KXX
• 分子名称: Basic fibroblast growth factor receptor 1, SULFATE ION (3 entities in total)
• 機能のキーワード: kinase, rtk, phosphorylation, interface, alternative splicing, atp-binding, chromosomal rearrangement, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72837.46

構造登録者

Bae, J.H.,Boggon, T.J.,Tome, F.,Mandiyan, V.,Lax, I.,Schlessinger, J. (登録日: 2009-12-04, 公開日: 2010-03-02, 最終更新日: 2023-09-06)

• 主引用文献: Bae, J.H.,Boggon, T.J.,Tome, F.,Mandiyan, V.,Lax, I.,Schlessinger, J.; Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.; Proc.Natl.Acad.Sci.USA, 107:2866-2871, 2010; PubMed: 20133753; DOI: 10.1073/pnas.0914157107

実験手法

X-RAY DIFFRACTION (2.7 Å)