3KXZ
The complex crystal structure of LCK with a probe molecule w259
Summary for 3KXZ
Entry DOI | 10.2210/pdb3kxz/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | lck, acetylation, atp-binding, cell membrane, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, kinase, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, polymorphism, proto-oncogene, transferase, tyrosine-protein kinase, structural genomics, protein structure factory, psf |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P06239 |
Total number of polymer chains | 1 |
Total formula weight | 33846.46 |
Authors | Xu, Z.B.,Moy, F.J.,Kelleher, K.,Mosyak, L.,Protein Structure Factory (PSF) (deposition date: 2009-12-04, release date: 2010-06-23, Last modification date: 2011-07-13) |
Primary citation | Moy, F.J.,Lee, A.,Gavrin, L.K.,Xu, Z.B.,Sievers, A.,Kieras, E.,Stochaj, W.,Mosyak, L.,McKew, J.,Tsao, D.H. Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance. J.Med.Chem., 53:1238-1249, 2010 Cited by PubMed: 20038108DOI: 10.1021/jm901525b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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