3KXZ

The complex crystal structure of LCK with a probe molecule w259

3KXZ の概要

• エントリーDOI: 10.2210/pdb3kxz/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: lck, acetylation, atp-binding, cell membrane, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, kinase, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, polymorphism, proto-oncogene, transferase, tyrosine-protein kinase, structural genomics, protein structure factory, psf
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33846.46

構造登録者

Xu, Z.B.,Moy, F.J.,Kelleher, K.,Mosyak, L.,Protein Structure Factory (PSF) (登録日: 2009-12-04, 公開日: 2010-06-23, 最終更新日: 2011-07-13)

• 主引用文献: Moy, F.J.,Lee, A.,Gavrin, L.K.,Xu, Z.B.,Sievers, A.,Kieras, E.,Stochaj, W.,Mosyak, L.,McKew, J.,Tsao, D.H.; Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.; J.Med.Chem., 53:1238-1249, 2010; PubMed: 20038108; DOI: 10.1021/jm901525b

実験手法

X-RAY DIFFRACTION (2.37 Å)