3KWF
human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
Summary for 3KWF
Entry DOI | 10.2210/pdb3kwf/pdb |
Related | 1NU6 1NU8 3KWH |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, (4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-(fluoromethyl)pyrrolidin-2-one, ... (4 entities in total) |
Functional Keywords | diabetes type ii, aminopeptidase, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 170564.97 |
Authors | Hennig, M.,Stihle, M.,Thoma, R. (deposition date: 2009-12-01, release date: 2010-01-12, Last modification date: 2020-07-29) |
Primary citation | Mattei, P.,Boehringer, M.,Di Giorgio, P.,Fischer, H.,Hennig, M.,Huwyler, J.,Kocer, B.,Kuhn, B.,Loeffler, B.M.,Macdonald, A.,Narquizian, R.,Rauber, E.,Sebokova, E.,Sprecher, U. Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg.Med.Chem.Lett., 20:1109-1113, 2010 Cited by PubMed: 20031405DOI: 10.1016/j.bmcl.2009.12.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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