3KVX

JNK3 bound to aminopyrimidine inhibitor, SR-3562

Summary for 3KVX

Entry DOI	10.2210/pdb3kvx/pdb
Descriptor	Mitogen-activated protein kinase 10, N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline (3 entities in total)
Functional Keywords	jnk3, mapk10, inhibitor, atp-binding, epilepsy, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P53779
Total number of polymer chains	1
Total formula weight	42694.38
Authors	Habel, J.E.,Laughlin, J.D.,LoGrasso, P. (deposition date: 2009-11-30, release date: 2009-12-22, Last modification date: 2023-09-06)
Primary citation	Kamenecka, T.,Jiang, R.,Song, X.,Duckett, D.,Chen, W.,Ling, Y.Y.,Habel, J.,Laughlin, J.D.,Chambers, J.,Figuera-Losada, M.,Cameron, M.D.,Lin, L.,Ruiz, C.H.,Lograsso, P.V. Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors J.Med.Chem., 53:419-431, 2010 Cited by PubMed: 19947601 DOI: 10.1021/jm901351f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation