3KVW

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand

Summary for 3KVW

• Entry DOI: 10.2210/pdb3kvw/pdb
• Related: 3K2L
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: dyrk2, dual-specificity tyrosine, ki-(y)-phosphorylation regulated kinase 2, psk-h2, kinase, structural genomics consortium, sgc, apoptosis, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92630
• Total number of polymer chains: 1
• Total formula weight: 50142.90

Authors

Filippakopoulos, P.,Myrianthopoulos, V.,Kritsanida, M.,Magiatis, P.,Skaltsounis, A.L.,Soundararajan, M.,Krojer, T.,Gileadi, O.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-11-30, release date: 2010-01-05, Last modification date: 2023-11-22)

• Primary citation: Filippakopoulos, P.,Myrianthopoulos, V.,Kritsanida, M.,Magiatis, P.,Skaltsounis, A.L.,Soundararajan, M.,Krojer, T.,Gileadi, O.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.; Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (2.28 Å)