3KVW

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand

3KVW の概要

• エントリーDOI: 10.2210/pdb3kvw/pdb
• 関連するPDBエントリー: 3K2L
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: dyrk2, dual-specificity tyrosine, ki-(y)-phosphorylation regulated kinase 2, psk-h2, kinase, structural genomics consortium, sgc, apoptosis, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q92630
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50142.90

構造登録者

Filippakopoulos, P.,Myrianthopoulos, V.,Kritsanida, M.,Magiatis, P.,Skaltsounis, A.L.,Soundararajan, M.,Krojer, T.,Gileadi, O.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-11-30, 公開日: 2010-01-05, 最終更新日: 2023-11-22)

• 主引用文献: Filippakopoulos, P.,Myrianthopoulos, V.,Kritsanida, M.,Magiatis, P.,Skaltsounis, A.L.,Soundararajan, M.,Krojer, T.,Gileadi, O.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.; Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand; To be Published,

実験手法

X-RAY DIFFRACTION (2.28 Å)