3KVQ

Crystal structure of VEGFR2 extracellular domain D7

3KVQ の概要

• エントリーDOI: 10.2210/pdb3kvq/pdb
• 分子名称: Vascular endothelial growth factor receptor 2 (2 entities in total)
• 機能のキーワード: vegfr2, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P35968
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11912.40

構造登録者

Yang, Y.,Opatowsky, Y.,Xie, P.,Schlessinger, J. (登録日: 2009-11-30, 公開日: 2010-02-16, 最終更新日: 2023-09-06)

• 主引用文献: Yang, Y.,Xie, P.,Opatowsky, Y.,Schlessinger, J.; Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling; Proc.Natl.Acad.Sci.USA, 107:1906-1911, 2010; PubMed: 20080685; DOI: 10.1073/pnas.0914052107

実験手法

X-RAY DIFFRACTION (2.7 Å)