3KT2
Crystal Structure of N88D mutant HIV-1 Protease
Summary for 3KT2
Entry DOI | 10.2210/pdb3kt2/pdb |
Related | 3KT5 |
Descriptor | Protease (2 entities in total) |
Functional Keywords | drug resistant mutation, n88d, nelfinavir, hiv-1 protease, hydrolase, protease |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 1 |
Total formula weight | 21964.85 |
Authors | Bihani, S.C.,Das, A.,Prashar, V.,Ferrer, J.L.,Hosur, M.V. (deposition date: 2009-11-24, release date: 2010-02-16, Last modification date: 2021-11-10) |
Primary citation | Bihani, S.C.,Das, A.,Prashar, V.,Ferrer, J.L.,Hosur, M.V. Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S. Biochem.Biophys.Res.Commun., 389:295-300, 2009 Cited by PubMed: 19720046DOI: 10.1016/j.bbrc.2009.08.138 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.651 Å) |
Structure validation
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