3KSQ
Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors
Summary for 3KSQ
Entry DOI | 10.2210/pdb3ksq/pdb |
Descriptor | Farnesyltransferase, CAAX box, alpha, Protein farnesyltransferase subunit beta, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | prenyltransferase, metal-binding, phosphoprotein, transferase |
Biological source | Rattus norvegicus (rat) More |
Total number of polymer chains | 2 |
Total formula weight | 93802.45 |
Authors | Zhu, H.Y.,Cooper, A.B.,Njoroge, G.,Kirschmeier, P.,Strickland, C.,Hruza, A.,Girijavallabhan, V.M. (deposition date: 2009-11-23, release date: 2010-01-26, Last modification date: 2023-09-06) |
Primary citation | Zhu, H.Y.,Cooper, A.B.,Desai, J.,Njoroge, G.,Kirschmeier, P.,Bishop, W.R.,Strickland, C.,Hruza, A.,Doll, R.J.,Girijavallabhan, V.M. Discovery of C-imidazole azaheptapyridine FPT inhibitors. Bioorg.Med.Chem.Lett., 20:1134-1136, 2010 Cited by PubMed: 20056542DOI: 10.1016/j.bmcl.2009.12.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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