3KQM

Crystal Structure of hPNMT in Complex AdoHcy and 4-Bromo-1H-imidazole

3KQM の概要

• エントリーDOI: 10.2210/pdb3kqm/pdb
• 関連するPDBエントリー: 3KPJ 3KPU 3KPV 3KPW 3KPY 3KQO 3KQP 3KQQ 3KQS 3KQT 3KQV 3KQW 3KQY 3KR0 3KR1 3KR2
• 分子名称: Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 4-bromo-1H-imidazole, ... (4 entities in total)
• 機能のキーワード: methyltransferase, fragment screening, catecholamine biosynthesis, s-adenosyl-l-methionine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64754.70

構造登録者

Drinkwater, N.,Martin, J.L. (登録日: 2009-11-17, 公開日: 2010-09-29, 最終更新日: 2023-09-06)

• 主引用文献: Drinkwater, N.,Vu, H.,Lovell, K.M.,Criscione, K.R.,Collins, B.M.,Prisinzano, T.E.,Poulsen, S.A.,McLeish, M.J.,Grunewald, G.L.,Martin, J.L.; Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.; Biochem.J., 431:51-61, 2010; PubMed: 20642456; DOI: 10.1042/BJ20100651

実験手法

X-RAY DIFFRACTION (2.4 Å)