3KQD
Factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4-yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)-one
Summary for 3KQD
Entry DOI | 10.2210/pdb3kqd/pdb |
Related | 3KQB 3KQC 3KQE |
Descriptor | factor Xa heavy chain, factor Xa light chain, 1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-6-(2'-(PYRROLIDIN-1-YLMETHYL)BIPHENYL-4-YL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN-7(4H)-ONE, ... (5 entities in total) |
Functional Keywords | glycoprotein, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, blood coagulation, calcium, protease, secreted, egf-like domain, gamma-carboxyglutamic acid, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 32681.92 |
Authors | Sheriff, S. (deposition date: 2009-11-17, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett., 20:1373-1377, 2010 Cited by PubMed: 20100660DOI: 10.1016/j.bmcl.2010.01.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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