3KQD
Factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4-yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)-one
3KQD の概要
エントリーDOI | 10.2210/pdb3kqd/pdb |
関連するPDBエントリー | 3KQB 3KQC 3KQE |
分子名称 | factor Xa heavy chain, factor Xa light chain, 1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-6-(2'-(PYRROLIDIN-1-YLMETHYL)BIPHENYL-4-YL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN-7(4H)-ONE, ... (5 entities in total) |
機能のキーワード | glycoprotein, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, blood coagulation, calcium, protease, secreted, egf-like domain, gamma-carboxyglutamic acid, hydrolase |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 32681.92 |
構造登録者 | |
主引用文献 | Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett., 20:1373-1377, 2010 Cited by PubMed: 20100660DOI: 10.1016/j.bmcl.2010.01.011 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.75 Å) |
構造検証レポート
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