3KQA

MurA dead-end complex with terreic acid

3KQA の概要

• エントリーDOI: 10.2210/pdb3kqa/pdb
• 関連するPDBエントリー: 3KQJ 3KR6
• 分子名称: UDP-N-acetylglucosamine 1-carboxyvinyltransferase, (5S)-2,5-dihydroxy-3-methylcyclohex-2-ene-1,4-dione, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: open enzyme state, inside-out alpha/beta barrel, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Enterobacter cloacae
• 細胞内の位置: Cytoplasm (Probable): P33038
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 180342.95

構造登録者

Schonbrunn, E. (登録日: 2009-11-17, 公開日: 2010-04-28, 最終更新日: 2023-09-06)

• 主引用文献: Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E.; The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .; Biochemistry, 49:4276-4282, 2010; PubMed: 20392080; DOI: 10.1021/bi100365b

実験手法

X-RAY DIFFRACTION (2.25 Å)