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3KPE

Solution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV

Summary for 3KPE
Entry DOI10.2210/pdb3kpe/pdb
DescriptorFusion glycoprotein F0, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywordspeptide-small-molecule complex, alpha helix, coiled-coil, envelope protein, fusion protein, glycoprotein, host cell membrane, host membrane, lipoprotein, membrane, palmitate, transmembrane, virion, viral protein
Biological sourceHuman respiratory syncytial virus
More
Cellular locationVirion membrane; Single-pass type I membrane protein: P03420 P03420
Total number of polymer chains2
Total formula weight10660.26
Authors
Roymans, D.,De Bondt, H.,Arnoult, E.,Cummings, M.D.,Van Vlijmen, H.,Andries, K. (deposition date: 2009-11-16, release date: 2009-12-22, Last modification date: 2023-09-06)
Primary citationRoymans, D.,De Bondt, H.L.,Arnoult, E.,Geluykens, P.,Gevers, T.,Van Ginderen, M.,Verheyen, N.,Kim, H.,Willebrords, R.,Bonfanti, J.F.,Bruinzeel, W.,Cummings, M.D.,van Vlijmen, H.,Andries, K.
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein.
Proc.Natl.Acad.Sci.USA, 107:308-313, 2010
Cited by
PubMed: 19966279
DOI: 10.1073/pnas.0910108106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.47 Å)
Structure validation

217705

數據於2024-03-27公開中

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