3KPE
Solution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV
Summary for 3KPE
Entry DOI | 10.2210/pdb3kpe/pdb |
Descriptor | Fusion glycoprotein F0, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | peptide-small-molecule complex, alpha helix, coiled-coil, envelope protein, fusion protein, glycoprotein, host cell membrane, host membrane, lipoprotein, membrane, palmitate, transmembrane, virion, viral protein |
Biological source | Human respiratory syncytial virus More |
Cellular location | Virion membrane; Single-pass type I membrane protein: P03420 P03420 |
Total number of polymer chains | 2 |
Total formula weight | 10660.26 |
Authors | Roymans, D.,De Bondt, H.,Arnoult, E.,Cummings, M.D.,Van Vlijmen, H.,Andries, K. (deposition date: 2009-11-16, release date: 2009-12-22, Last modification date: 2023-09-06) |
Primary citation | Roymans, D.,De Bondt, H.L.,Arnoult, E.,Geluykens, P.,Gevers, T.,Van Ginderen, M.,Verheyen, N.,Kim, H.,Willebrords, R.,Bonfanti, J.F.,Bruinzeel, W.,Cummings, M.D.,van Vlijmen, H.,Andries, K. Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein. Proc.Natl.Acad.Sci.USA, 107:308-313, 2010 Cited by PubMed: 19966279DOI: 10.1073/pnas.0910108106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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