3KPE

Solution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV

3KPE の概要

• エントリーDOI: 10.2210/pdb3kpe/pdb
• 分子名称: Fusion glycoprotein F0, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: peptide-small-molecule complex, alpha helix, coiled-coil, envelope protein, fusion protein, glycoprotein, host cell membrane, host membrane, lipoprotein, membrane, palmitate, transmembrane, virion, viral protein
• 由来する生物種: Human respiratory syncytial virus; 詳細
• 細胞内の位置: Virion membrane; Single-pass type I membrane protein: P03420 P03420
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 10660.26

構造登録者

Roymans, D.,De Bondt, H.,Arnoult, E.,Cummings, M.D.,Van Vlijmen, H.,Andries, K. (登録日: 2009-11-16, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Roymans, D.,De Bondt, H.L.,Arnoult, E.,Geluykens, P.,Gevers, T.,Van Ginderen, M.,Verheyen, N.,Kim, H.,Willebrords, R.,Bonfanti, J.F.,Bruinzeel, W.,Cummings, M.D.,van Vlijmen, H.,Andries, K.; Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein.; Proc.Natl.Acad.Sci.USA, 107:308-313, 2010; PubMed: 19966279; DOI: 10.1073/pnas.0910108106

実験手法

X-RAY DIFFRACTION (1.47 Å)