3KNX

HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor

3KNX の概要

• エントリーDOI: 10.2210/pdb3knx/pdb
• 関連するPDBエントリー: 3EYD
• 分子名称: HCV NS3 Protease, HCV NS4a peptide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: hepatitis c virus, ns3 protease domain, serine protease, macrocyclic ketoamide inhibitor, atp-binding, envelope protein, helicase, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, viral protein
• 由来する生物種: Hepatitis C virus subtype 1a; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48192.44

構造登録者

Venkatraman, S.,Velazquez, F.,Wu, W.,Blackman, M.,Chen, K.X.,Bogen, S.,Nair, L.,Tong, X.,Chase, R.,Hart, A.,Agrawal, S.,Pichardo, J.,Prongay, A.,Cheng, K.-C.,Girijavallabhan, V.,Piwinski, J.,Shih, N.-Y.,Njoroge, F.G. (登録日: 2009-11-12, 公開日: 2010-10-27, 最終更新日: 2024-04-03)

• 主引用文献: Venkatraman, S.,Velazquez, F.,Wu, W.,Blackman, M.,Chen, K.X.,Bogen, S.,Nair, L.,Tong, X.,Chase, R.,Hart, A.,Agrawal, S.,Pichardo, J.,Prongay, A.,Cheng, K.C.,Girijavallabhan, V.,Piwinski, J.,Shih, N.Y.,Njoroge, F.G.; Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.; J.Med.Chem., 52:336-346, 2009; PubMed: 19102654; DOI: 10.1021/jm800940u

実験手法

X-RAY DIFFRACTION (2.65 Å)