3KN2
HCV NS3 Protease Domain with ketoamide inhibitor
Summary for 3KN2
Entry DOI | 10.2210/pdb3kn2/pdb |
Descriptor | HCV NS3 Protease Domain, Peptide KK-NS4A-KK, ZINC ION, ... (5 entities in total) |
Functional Keywords | hepatitis c virus, ns3 protease domain, serine protease, ketoamide inhibitor, atp-binding, capsid protein, envelope protein, helicase, host membrane, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, virion |
Biological source | Hepatitis C virus subtype 1a More |
Total number of polymer chains | 4 |
Total formula weight | 48104.27 |
Authors | Nair, L.G.,Sannigrahi, M.,Pinto, P.,Bogen, S.,Chen, K.X.,Njoroge, G.,Prongay, A. (deposition date: 2009-11-11, release date: 2010-01-19, Last modification date: 2021-10-13) |
Primary citation | Nair, L.G.,Sannigrahi, M.,Bogen, S.,Pinto, P.,Chen, K.X.,Prongay, A.,Tong, X.,Cheng, K.C.,Girijavallabhan, V.,George Njoroge, F. P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile. Bioorg.Med.Chem.Lett., 20:567-570, 2010 Cited by PubMed: 20004570DOI: 10.1016/j.bmcl.2009.11.094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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