3KN2

HCV NS3 Protease Domain with ketoamide inhibitor

Summary for 3KN2

Entry DOI	10.2210/pdb3kn2/pdb
Descriptor	HCV NS3 Protease Domain, Peptide KK-NS4A-KK, ZINC ION, ... (5 entities in total)
Functional Keywords	hepatitis c virus, ns3 protease domain, serine protease, ketoamide inhibitor, atp-binding, capsid protein, envelope protein, helicase, host membrane, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, virion
Biological source	Hepatitis C virus subtype 1a More
Total number of polymer chains	4
Total formula weight	48104.27
Authors	Nair, L.G.,Sannigrahi, M.,Pinto, P.,Bogen, S.,Chen, K.X.,Njoroge, G.,Prongay, A. (deposition date: 2009-11-11, release date: 2010-01-19, Last modification date: 2021-10-13)
Primary citation	Nair, L.G.,Sannigrahi, M.,Bogen, S.,Pinto, P.,Chen, K.X.,Prongay, A.,Tong, X.,Cheng, K.C.,Girijavallabhan, V.,George Njoroge, F. P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile. Bioorg.Med.Chem.Lett., 20:567-570, 2010 Cited by PubMed: 20004570 DOI: 10.1016/j.bmcl.2009.11.094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation