3KMM

Structure of human LCK kinase with a small molecule inhibitor

3KMM の概要

• エントリーDOI: 10.2210/pdb3kmm/pdb
• 関連するPDBエントリー: 3LCK
• 分子名称: Proto-oncogene tyrosine-protein kinase LCK, 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: tyrosine kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, transferase, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34134.64

構造登録者

Graves, B.J.,Surgenor, A.,Harris, W.,Smith, I.,Orchard, S.,Flotow, H.,Murray, E. (登録日: 2009-11-10, 公開日: 2010-12-08, 最終更新日: 2023-11-22)

• 主引用文献: Graves, B.J.,Surgenor, A.,Harris, W.,Smith, I.,Orchard, S.,Flotow, H.,Murray, E.; Structure of human LCK kinase with a small molecule inhibitor; To be Published,

実験手法

X-RAY DIFFRACTION (2.8 Å)