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3KMD

Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer

Summary for 3KMD
Entry DOI10.2210/pdb3kmd/pdb
DescriptorCellular tumor antigen p53, 5'-D(*GP*GP*GP*CP*AP*TP*GP*CP*CP*TP*AP*GP*GP*CP*AP*TP*GP*CP*C)-3', ZINC ION, ... (4 entities in total)
Functional Keywordsp53 core domain, protein-dna interaction, self assembled tetramer, activator, apoptosis, cell cycle, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, isopeptide bond, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, tumor suppressor, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains6
Total formula weight102073.67
Authors
Chen, Y.,Dey, R.,Chen, L. (deposition date: 2009-11-10, release date: 2010-02-23, Last modification date: 2023-09-06)
Primary citationChen, Y.,Dey, R.,Chen, L.
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
Structure, 18:246-256, 2010
Cited by
PubMed: 20159469
DOI: 10.1016/j.str.2009.11.011
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

217705

數據於2024-03-27公開中

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