3KFY
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
Summary for 3KFY
Entry DOI | 10.2210/pdb3kfy/pdb |
Related | 1DHF 3K45 |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine, ... (5 entities in total) |
Functional Keywords | small molecule inhibitor, dynamics, antibiotic resistance, methotrexate resistance, nadp, one-carbon metabolism, oxidoreductase, trimethoprim resistance |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19188.76 |
Authors | Collins, E.J.,Lee, A.L.,Carroll, M.J.,Gromova, A.V.,Miller, K.R.,Singleton, S.F. (deposition date: 2009-10-28, release date: 2010-12-08, Last modification date: 2023-09-06) |
Primary citation | Collins, E.J.,Lee, A.L.,Carroll, M.J.,Gromova, A.V.,Miller, K.R.,Singleton, S.F. Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR To be Published, |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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