3KFY

Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR

3KFY の概要

• エントリーDOI: 10.2210/pdb3kfy/pdb
• 関連するPDBエントリー: 1DHF 3K45
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine, ... (5 entities in total)
• 機能のキーワード: small molecule inhibitor, dynamics, antibiotic resistance, methotrexate resistance, nadp, one-carbon metabolism, oxidoreductase, trimethoprim resistance
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19188.76

構造登録者

Collins, E.J.,Lee, A.L.,Carroll, M.J.,Gromova, A.V.,Miller, K.R.,Singleton, S.F. (登録日: 2009-10-28, 公開日: 2010-12-08, 最終更新日: 2023-09-06)

• 主引用文献: Collins, E.J.,Lee, A.L.,Carroll, M.J.,Gromova, A.V.,Miller, K.R.,Singleton, S.F.; Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR; To be Published,

実験手法

X-RAY DIFFRACTION (2.08 Å)