3KF4

Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

3KF4 の概要

• エントリーDOI: 10.2210/pdb3kf4/pdb
• 関連するPDBエントリー: 3KFA
• 分子名称: Tyrosine-protein kinase ABL1, N-[4-(dimethylphosphoryl)phenyl]-9-[(E)-2-(5-methyl-1H-indazol-4-yl)ethenyl]-9H-purin-6-amine (3 entities in total)
• 機能のキーワード: abl, cml, drug resistance, inhibitor, atp-binding, kinase, nucleotide-binding, oncogene, tyrosine-protein kinase, transferase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm, cytoskeleton: P00520
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67370.81

構造登録者

Zhou, T. (登録日: 2009-10-27, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Zhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Sawyer, T.K.,Shakespeare, W.C.,Clackson, T.,Zhu, X.,Dalgarno, D.C.; Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.; Chem.Biol.Drug Des., 75:18-28, 2010; PubMed: 19895503; DOI: 10.1111/j.1747-0285.2009.00905.x

実験手法

X-RAY DIFFRACTION (1.9 Å)