3KEX

Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)

3KEX の概要

• エントリーDOI: 10.2210/pdb3kex/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: kinase domain, inactive kinase, her3, erbb3, atp-binding, cell membrane, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73959.42

構造登録者

Jura, N.,Shan, Y.,Cao, X.,Shaw, D.E.,Kuriyan, J. (登録日: 2009-10-26, 公開日: 2009-12-22, 最終更新日: 2024-04-03)

• 主引用文献: Jura, N.,Shan, Y.,Cao, X.,Shaw, D.E.,Kuriyan, J.; Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.; Proc.Natl.Acad.Sci.USA, 106:21608-21613, 2009; PubMed: 20007378; DOI: 10.1073/pnas.0912101106

実験手法

X-RAY DIFFRACTION (2.797 Å)