3KDU

Crystal structure of peroxisome proliferator-activatedeceptor alpha (PPARalpha) complex with N-3-((2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy)benzyl)-N-((4-methylphenoxy)carbonyl)glycine

3KDU の概要

• エントリーDOI: 10.2210/pdb3kdu/pdb
• 関連するPDBエントリー: 3KDT
• 分子名称: Peroxisome proliferator-activated receptor alpha, N-(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-[(4-methylphenoxy)carbonyl]glycine (3 entities in total)
• 機能のキーワード: nuclear hormone receptor, transcription regulation, activator, dna-binding, lipid-binding, receptor, transcription, hormone receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q07869
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63674.81

構造登録者

Muckelbauer, J.K. (登録日: 2009-10-23, 公開日: 2010-04-28, 最終更新日: 2023-09-06)

• 主引用文献: Li, J.,Kennedy, L.J.,Shi, Y.,Tao, S.,Ye, X.Y.,Chen, S.Y.,Wang, Y.,Hernandez, A.S.,Wang, W.,Devasthale, P.V.,Chen, S.,Lai, Z.,Zhang, H.,Wu, S.,Smirk, R.A.,Bolton, S.A.,Ryono, D.E.,Zhang, H.,Lim, N.K.,Chen, B.C.,Locke, K.T.,O'Malley, K.M.,Zhang, L.,Srivastava, R.A.,Miao, B.,Meyers, D.S.,Monshizadegan, H.,Search, D.,Grimm, D.,Zhang, R.,Harrity, T.,Kunselman, L.K.,Cap, M.,Kadiyala, P.,Hosagrahara, V.,Zhang, L.,Xu, C.,Li, Y.X.,Muckelbauer, J.K.,Chang, C.,An, Y.,Krystek, S.R.,Blanar, M.A.,Zahler, R.,Mukherjee, R.,Cheng, P.T.,Tino, J.A.; Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).; J.Med.Chem., 53:2854-2864, 2010; PubMed: 20218621; DOI: 10.1021/jm9016812

実験手法

X-RAY DIFFRACTION (2.07 Å)