3KDB
Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006
Summary for 3KDB
Entry DOI | 10.2210/pdb3kdb/pdb |
Related | 2PK5 2PK6 3KDC 3KDD |
Related PRD ID | PRD_000575 |
Descriptor | Protease, GLYCEROL, (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, ... (4 entities in total) |
Functional Keywords | viral protein, hydrolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22333.49 |
Authors | Chufan, E.E.,Lafont, V.,Freire, E.,Amzel, L.M. (deposition date: 2009-10-22, release date: 2010-03-02, Last modification date: 2023-09-06) |
Primary citation | Kawasaki, Y.,Chufan, E.E.,Lafont, V.,Hidaka, K.,Kiso, Y.,Mario Amzel, L.,Freire, E. How much binding affinity can be gained by filling a cavity? Chem.Biol.Drug Des., 75:143-151, 2010 Cited by PubMed: 20028396DOI: 10.1111/j.1747-0285.2009.00921.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
Download full validation report