3KBA

Progesterone receptor bound to sulfonamide pyrrolidine partial agonist

Summary for 3KBA

Entry DOI	10.2210/pdb3kba/pdb
Descriptor	Progesterone receptor, 2-chloro-4-{(2-methylbenzyl)[(3S)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}benzonitrile, SULFATE ION, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription, transcription regulation
Biological source	Homo sapiens (human)
Cellular location	Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
Total number of polymer chains	2
Total formula weight	59412.65
Authors	Kallander, L.S.,Washburn, D.G.,Williams, S.P.,Madauss, K.P. (deposition date: 2009-10-20, release date: 2009-12-08, Last modification date: 2024-02-21)
Primary citation	Kallander, L.S.,Washburn, D.G.,Hoang, T.H.,Frazee, J.S.,Stoy, P.,Johnson, L.,Lu, Q.,Hammond, M.,Barton, L.S.,Patterson, J.R.,Azzarano, L.M.,Nagilla, R.,Madauss, K.P.,Williams, S.P.,Stewart, E.L.,Duraiswami, C.,Grygielko, E.T.,Xu, X.,Laping, N.J.,Bray, J.D.,Thompson, S.K. Improving the developability profile of pyrrolidine progesterone receptor partial agonists. Bioorg.Med.Chem.Lett., 20:371-374, 2010 Cited by PubMed: 19926282 DOI: 10.1016/j.bmcl.2009.10.092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation