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3KB7

Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor

Summary for 3KB7
Entry DOI10.2210/pdb3kb7/pdb
DescriptorSerine/threonine-protein kinase PLK1, 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, ZINC ION, ... (5 entities in total)
Functional Keywordsprotein kinase, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P53350
Total number of polymer chains1
Total formula weight36323.56
Authors
Bossi, R.T.,Bertrand, J.A. (deposition date: 2009-10-20, release date: 2010-05-19, Last modification date: 2011-07-13)
Primary citationBeria, I.,Ballinari, D.,Bertrand, J.A.,Borghi, D.,Bossi, R.T.,Brasca, M.G.,Cappella, P.,Caruso, M.,Ceccarelli, W.,Ciavolella, A.,Cristiani, C.,Croci, V.,De Ponti, A.,Fachin, G.,Ferguson, R.D.,Lansen, J.,Moll, J.K.,Pesenti, E.,Posteri, H.,Perego, R.,Rocchetti, M.,Storici, P.,Volpi, D.,Valsasina, B.
Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors
J.Med.Chem., 53:3532-3551, 2010
Cited by
PubMed: 20397705
DOI: 10.1021/jm901713n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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