3KB7

Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor

3KB7 の概要

• エントリーDOI: 10.2210/pdb3kb7/pdb
• 分子名称: Serine/threonine-protein kinase PLK1, 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: protein kinase, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P53350
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36323.56

構造登録者

Bossi, R.T.,Bertrand, J.A. (登録日: 2009-10-20, 公開日: 2010-05-19, 最終更新日: 2024-04-03)

• 主引用文献: Beria, I.,Ballinari, D.,Bertrand, J.A.,Borghi, D.,Bossi, R.T.,Brasca, M.G.,Cappella, P.,Caruso, M.,Ceccarelli, W.,Ciavolella, A.,Cristiani, C.,Croci, V.,De Ponti, A.,Fachin, G.,Ferguson, R.D.,Lansen, J.,Moll, J.K.,Pesenti, E.,Posteri, H.,Perego, R.,Rocchetti, M.,Storici, P.,Volpi, D.,Valsasina, B.; Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors; J.Med.Chem., 53:3532-3551, 2010; PubMed: 20397705; DOI: 10.1021/jm901713n

実験手法

X-RAY DIFFRACTION (2.5 Å)