3KA0

MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2-hydroxyphenyl)-N-methylbenzo[b]thiophene-2-carboxamide

3KA0 の概要

• エントリーDOI: 10.2210/pdb3ka0/pdb
• 関連するPDBエントリー: 3KC3
• 分子名称: MAP kinase-activated protein kinase 2, 6-{5-[(2-aminopyrimidin-4-yl)amino]-2-hydroxyphenyl}-N-methylidene-1-benzothiophene-2-carboxamide (3 entities in total)
• 機能のキーワード: mapkap-k2, mk2, tnfalpha, diaminopyrimidine, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37377.14

構造登録者

Argiriadi, M.A.,Talanian, R.V.,Borhani, D.W. (登録日: 2009-10-16, 公開日: 2010-01-12, 最終更新日: 2024-02-21)

• 主引用文献: Argiriadi, M.A.,Ericsson, A.M.,Harris, C.M.,Banach, D.L.,Borhani, D.W.,Calderwood, D.J.,Demers, M.D.,Dimauro, J.,Dixon, R.W.,Hardman, J.,Kwak, S.,Li, B.,Mankovich, J.A.,Marcotte, D.,Mullen, K.D.,Ni, B.,Pietras, M.,Sadhukhan, R.,Sousa, S.,Tomlinson, M.J.,Wang, L.,Xiang, T.,Talanian, R.V.; 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.; Bioorg.Med.Chem.Lett., 20:330-333, 2010; PubMed: 19919896; DOI: 10.1016/j.bmcl.2009.10.102

実験手法

X-RAY DIFFRACTION (2.9 Å)