3K97

HSP90 N-terminal domain in complex with 4-chloro-6-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol

3K97 の概要

• エントリーDOI: 10.2210/pdb3k97/pdb
• 関連するPDBエントリー: 3K98 3K99
• 分子名称: Heat shock protein HSP 90-alpha, 4-chloro-6-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: hsp90, atp binding domain, n-terminal domain, inhibition, acetylation, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28882.84

構造登録者

Gajiwala, K.S. (登録日: 2009-10-15, 公開日: 2010-02-09, 最終更新日: 2024-02-21)

• 主引用文献: Kung, P.P.,Huang, B.,Zhang, G.,Zhou, J.Z.,Wang, J.,Digits, J.A.,Skaptason, J.,Yamazaki, S.,Neul, D.,Zientek, M.,Elleraas, J.,Mehta, P.,Yin, M.J.,Hickey, M.J.,Gajiwala, K.S.,Rodgers, C.,Davies, J.F.,Gehring, M.R.; Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.; J.Med.Chem., 53:499-503, 2010; PubMed: 19908836; DOI: 10.1021/jm901209q

実験手法

X-RAY DIFFRACTION (1.95 Å)