3K5K
Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a
Summary for 3K5K
Entry DOI | 10.2210/pdb3k5k/pdb |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total) |
Functional Keywords | histone lysine methyltransferase, g9a, ank repeat, chromatin regulator, metal-binding, methyltransferase, nucleus, phosphoprotein, s-adenosyl-l-methionine, transferase, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q96KQ7 |
Total number of polymer chains | 2 |
Total formula weight | 67615.08 |
Authors | Dong, A.,Wasney, G.A.,Liu, F.,Chen, X.,Allali-Hassani, A.,Senisterra, G.,Chau, I.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Frye, S.V.,Bochkarev, A.,Brown, P.J.,Jin, J.,Vedadi, M.,Structural Genomics Consortium (SGC) (deposition date: 2009-10-07, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Liu, F.,Chen, X.,Allali-Hassani, A.,Quinn, A.M.,Wasney, G.A.,Dong, A.,Barsyte, D.,Kozieradzki, I.,Senisterra, G.,Chau, I.,Siarheyeva, A.,Kireev, D.B.,Jadhav, A.,Herold, J.M.,Frye, S.V.,Arrowsmith, C.H.,Brown, P.J.,Simeonov, A.,Vedadi, M.,Jin, J. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem., 52:7950-7953, 2009 Cited by PubMed: 19891491DOI: 10.1021/jm901543m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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