3K5K
Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a
3K5K の概要
エントリーDOI | 10.2210/pdb3k5k/pdb |
分子名称 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total) |
機能のキーワード | histone lysine methyltransferase, g9a, ank repeat, chromatin regulator, metal-binding, methyltransferase, nucleus, phosphoprotein, s-adenosyl-l-methionine, transferase, structural genomics, structural genomics consortium, sgc |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus : Q96KQ7 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 67615.08 |
構造登録者 | Dong, A.,Wasney, G.A.,Liu, F.,Chen, X.,Allali-Hassani, A.,Senisterra, G.,Chau, I.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Frye, S.V.,Bochkarev, A.,Brown, P.J.,Jin, J.,Vedadi, M.,Structural Genomics Consortium (SGC) (登録日: 2009-10-07, 公開日: 2009-11-10, 最終更新日: 2023-09-06) |
主引用文献 | Liu, F.,Chen, X.,Allali-Hassani, A.,Quinn, A.M.,Wasney, G.A.,Dong, A.,Barsyte, D.,Kozieradzki, I.,Senisterra, G.,Chau, I.,Siarheyeva, A.,Kireev, D.B.,Jadhav, A.,Herold, J.M.,Frye, S.V.,Arrowsmith, C.H.,Brown, P.J.,Simeonov, A.,Vedadi, M.,Jin, J. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem., 52:7950-7953, 2009 Cited by PubMed: 19891491DOI: 10.1021/jm901543m 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
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