3K5D

Crystal Structure of BACE-1 in complex with AHM178

3K5D の概要

• エントリーDOI: 10.2210/pdb3k5d/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000675
• 分子名称: Beta-secretase 1, N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-methioninamide (3 entities in total)
• 機能のキーワード: aspartyl protease, alzheimer's disease, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, membrane, protease, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 137939.24

構造登録者

Rondeau, J.-M. (登録日: 2009-10-07, 公開日: 2010-05-05, 最終更新日: 2017-11-01)

• 主引用文献: Hanessian, S.,Shao, Z.,Betschart, C.,Rondeau, J.M.,Neumann, U.,Tintelnot-Blomley, M.; Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.; Bioorg.Med.Chem.Lett., 20:1924-1927, 2010; PubMed: 20172717; DOI: 10.1016/j.bmcl.2010.01.139

実験手法

X-RAY DIFFRACTION (2.9 Å)