3K3Q

Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain

3K3Q の概要

• エントリーDOI: 10.2210/pdb3k3q/pdb
• 分子名称: llama Aa1 VHH domain, Botulinum neurotoxin type A, ZINC ION, ... (5 entities in total)
• 機能のキーワード: llama, vhh, antibody, botulinum, neurotoxin, bont, cell junction, cell membrane, cytoplasm, disulfide bond, hydrolase, membrane, metal-binding, metalloprotease, pharmaceutical, protease, secreted, synapse, toxin, transmembrane, zinc, immune system
• 由来する生物種: Lama glama; 詳細
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 A5HZZ9
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 65194.77

構造登録者

Thompson, A.A.,Dong, J.,Marks, J.D.,Stevens, R.C. (登録日: 2009-10-04, 公開日: 2010-02-23, 最終更新日: 2017-11-01)

• 主引用文献: Dong, J.,Thompson, A.A.,Fan, Y.,Lou, J.,Conrad, F.,Ho, M.,Pires-Alves, M.,Wilson, B.A.,Stevens, R.C.,Marks, J.D.; A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.; J.Mol.Biol., 397:1106-1118, 2010; PubMed: 20138889; DOI: 10.1016/j.jmb.2010.01.070

実験手法

X-RAY DIFFRACTION (2.6 Å)