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3K3J

P38alpha bound to novel DFG-out compound PF-00416121

Summary for 3K3J
Entry DOI10.2210/pdb3k3j/pdb
DescriptorMitogen-activated protein kinase 14, 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total)
Functional Keywordsp38alpha kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): Q16539
Total number of polymer chains1
Total formula weight42212.96
Authors
Kazmirski, S.L.,DiNitto, J.P. (deposition date: 2009-10-02, release date: 2009-11-10, Last modification date: 2024-02-21)
Primary citationTecle, H.,Feru, F.,Liu, H.,Kuhn, C.,Rennie, G.,Morris, M.,Shao, J.,Cheng, A.C.,Gikunju, D.,Miret, J.,Coli, R.,Xi, S.H.,Clugston, S.L.,Low, S.,Kazmirski, S.,Ding, Y.H.,Cao, Q.,Johnson, T.L.,Deshmukh, G.D.,Dinitto, J.P.,Wu, J.C.,English, J.M.
The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay.
Chem.Biol.Drug Des., 74:547-559, 2009
Cited by
PubMed: 19843080
DOI: 10.1111/j.1747-0285.2009.00884.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.995 Å)
Structure validation

217705

數據於2024-03-27公開中

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