3K3J

P38alpha bound to novel DFG-out compound PF-00416121

3K3J の概要

• エントリーDOI: 10.2210/pdb3k3j/pdb
• 分子名称: Mitogen-activated protein kinase 14, 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total)
• 機能のキーワード: p38alpha kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42212.96

構造登録者

Kazmirski, S.L.,DiNitto, J.P. (登録日: 2009-10-02, 公開日: 2009-11-10, 最終更新日: 2024-02-21)

• 主引用文献: Tecle, H.,Feru, F.,Liu, H.,Kuhn, C.,Rennie, G.,Morris, M.,Shao, J.,Cheng, A.C.,Gikunju, D.,Miret, J.,Coli, R.,Xi, S.H.,Clugston, S.L.,Low, S.,Kazmirski, S.,Ding, Y.H.,Cao, Q.,Johnson, T.L.,Deshmukh, G.D.,Dinitto, J.P.,Wu, J.C.,English, J.M.; The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay.; Chem.Biol.Drug Des., 74:547-559, 2009; PubMed: 19843080; DOI: 10.1111/j.1747-0285.2009.00884.x

実験手法

X-RAY DIFFRACTION (1.995 Å)